Ocular toxicity from systemically administered xenobiotics

Ocular toxicity assessment from systemically administered xenobiotics: considerations in drug development.

The eye is a unique sensory structure, which must be evaluated for toxicity to determine the safety of drugs, industrial chemicals, and consumer products. Changes in the structure and/or function of ocular tissues following systemic administration of a potential new drug in preclinical animal models can result in significant delays in the development of a new therapeutic and in some cases lead ...

White-light toxicity, resulting from systemically administered 5-aminolevulinic acid, under normal operating conditions.

This study has investigated damage to the intraperitoneal organs of the rat after systemic (intraperitoneal and intravenous) administration of low doses of 5-aminolevulinic acid (ALA) and illumination with a standard white-light operating-room (o.r.) lamp. The study has been done within the framework of a larger study in which the possibility of using ALA for localization of small-volume macros...

Ocular toxicity from ethambutol.

Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs

This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and excretion and potential drug-drug interactions. This overview provides an understanding of their clinical pharmacokinetics, which could assist in ...

The acute toxicity of high doses of systemically administered formocresol in dogs.

Formocresol applied to vital pulp tissue may be absorbed systemically. The possible effect of the systemic absorption of formocresol is unknown. The purpose of this project was to determine the acute toxic effect of systemically administered formocresol. Two dogs were anesthetized and Buckley’s formocresol was administered i.v. a t doses of 0.05 and 0.1 5 ml/kg respectively. Blood pressure and ...